New paper on Xpo7 in Hedgehog signaling

The preprint that we had posted a while back on biorXiv has finally been published! Łukasz and the team showed that the unconventional nuclear export protein Xpo7 is important in keeping Gli proteins out of the nucleus to prevent excessive Hedgehog pathway activation when there is no ligand in the environment. Xpo7 and another exportin Xpo1 work together with a major negative regulator of the Hh pathway known as SuFu. The paper used many innovative approaches, including CRISPR/Cas9 mutagenesis and our custom-made software for nuclear localization quantification in hundreds of cells. The paper was the culmination of Łukasz’s work as part of his FUGA fellowship in our lab. Huge congratulations to the whole team!

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