We currently pursue several lines of research. Our main focus is on how Gli proteins are regulated in Hedgehog signaling. These proteins play a central role in many types of cancer and undergo a very interesting and largely unknown process of conversion into either transcriptional activators or repressors. One of the more enigmatic aspects of Gli protein regulation is their transport into tips of primary cilia, microtubule based organelles that are involved in the pathogenesis of many human diseases. We want to understand how Gli proteins are transported into cilia and why this transport is required for the function of these transcription factors. Another goal of our research is to decipher the transcriptional regulation of carcinogenesis with particular focus on the Hedgehog-driven cancer medulloblastoma. Finally, we have recently started leveraging large scale genomic, epigenomic, transcriptomic, and screening data to search for novel druggable oncoproteins in many cancers, including melanoma.

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