New funding to explore Gli repression

Gli proteins are bifunctional – they can act as transcriptional activators, but they can also block transcription in the absence of the ligand. Whereas Gli-mediated activation of transcription is well studied, less is known about Gli-dependent repression of target genes. In a project that had just received over PLN 2 million in funding from the National Science Centre, we will be exploring the function of Gli repressors using methods ranging from large-scale genetic screening using CRISPR-Cas9 to next generation sequencing methods such as ChIP-Seq. We will be recruiting PhD students and postdocs for the new grant, so please stay tuned if you are interested in joining.

Comments are closed.